![]() ![]() FFP did not influence INR values at 48 hours. Home warfarin dose did not affect INR responses to intravenous (p = 0.27) or oral vitamin K (p = 0.98). The INR reduction was similar for intravenous vitamin K doses 2 mg or greater. The dose of vitamin K (p < 0.001), route of administration (p < 0.001), and baseline INR (p < 0.001) influenced subsequent INR values. Intravenous vitamin K reduced INR more rapidly than oral vitamin K (5.09, 1.91, 1.54, and 1.41 vs 5.67, 2.90, 2.14, and 1.58) at baseline, 12, 24, and 48 hours, respectively. Data collected included international normalized ratios (INRs) 12 hours, 24 hours, and 48 hours prior to vitamin K administration intravenous or oral vitamin K dose and whether or not fresh frozen plasma (FFP) was administered. This was a chart review of 400 patients who received vitamin K for reversal of warfarin effects between February 2008 and November 2010. To determine factors influencing the extent and rate of INR reversal with vitamin K in the acute/critical care setting. However, the optimal dose and route of vitamin K that does not increase the duration of bridging therapy is unknown. K per os every week till age one month, and for exclusively breast feeded children till age 6 months ).Vitamin K is commonly used for reversal of anticoagulation of warfarin. K intramuscularly 2–6 hours after birth and then 1 mg of vit. It may also be the cause of haemorrhagic disease of newborn, because placental transfer of vitamin K is very low, its level in breast milk is low as well. ![]() It can cause excessive bleeding and increased tendency to bruise. It is very rare in adults, but can occur in individuals that cannot absorb it properly, due to lack of intestinal bacteria, as well as those being treated long term with antibiotics. Note: Vitamin K is an antidote for warfarin. Therefore if a person is taking blood-thinning agents, they may need to limit the amount of Vitamin K intake. This can cause the breakdown of red blood cells and also liver damage.
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